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KMID : 1137820180390060237
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의공학회지
2018 Volume.39 No. 6 p.237 ~ p.242
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Region of Interest Analysis for Standardized Uptake Value Ratio of 18F-fludeoxyglucose PET: Mild Cognitive Impairment and Alzheimer’s Disease
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Kim Seon-Jik
Yoon Ui-Cheul
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Abstract
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18F-fludeoxyglucose PET (FDG-PET) can help finding an abnormal metabolic activity in brain. In this study, we evaluated an efficiency of volume- and cortical surface-based analysis which were used to determine whether standardized uptake value ratio (SUVR) of FDG-PET was different among Alzheimer’s disease (AD), mild cognitive impairment (MCI), and healthy control (HC). Each PET image was rigidly co-registered to the corresponding magnetic resonance imaging (MRI) using mutual information. All voxels of the co-registered PET images were divided by the mean FDG uptake of the cerebellum cortex which was thresholded by partial volume effect (>0.9). Also, the SUVR value of each vertex was linearly interpolated from volumetric SUVR image which was thresholded by gray matter partial volume effect (>0.1). Lobar mean values were calculated from both volume- and cortical surface-based SUVRs. Statistical analysis was conducted to compare two measures for AD, MCI and HC groups. Even though the results of volume (SUVR_vol) and cortical surface-based SUVR (SUVR_surf) analysis were not significantly different from each other, the latter would be better for detecting group differences in SUVR of PET.
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KEYWORD
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Standardized uptake value ratio (SUVR), Volume-based SUVR (SUVR_vol), Cortical surfacebased SUVR (SUVR_surf), 18F-fludeoxyglucose (FDG), Positron emission tomography (PET), Magnetic resonance imaging (MRI)
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